I have been running 64-bit Vista for ages....over two years on my laptop and longer on one of my desktop computers.

Nevo Studio Pro is the only program I have ever run into that won't run on them.  It's been through enough updates now that I don't think annoyance equates with impatience anymore. 

At this point, this is beyond inconvenience. They really are behind the curve.  I went to Costco to buy a new computer for my parents last month-  every single model they sold came with a 64-bit operating system.