Question.....are you using Windows XP? I was having the exact same problem....everything worked great except iProntoedit could not "find" my iPronto. That is until I decided to drag my old PC out of the closet that uses windows 98 and try downloading/uploading with that machine....with the windows '98 pc, it works perfectly...finds the iPronto every time. This is not much of a solution if you don't have a backup PC, but it would interest me if you use XP as well. FYI....iPronot support is very very weak on this topic. I finally quit trying to have them give me a solution...they came up with nothing but very unhelpful, elementary ideas...