Going back to your original question: I purchased the MX-350 as a replacement for a RF-20. The main reasons:

1. The backlighting on the RF-20 is terrible. It's red, it's uneven, and it's dim even with brand new batteries. The light (such as it is) shines through just the text that is etched into the buttons. There simply is not enough light coming through to make the text legible in the dark. To me this essentially defeats the purpose of backlighting. On the MX-350, the buttons are completely illuminated, and the text stays dark. As such, the text is actually back-lit, making it far more legible in the dark.

2. The 4-way controller on the RF-20 has a mushy, cheap feel to it, with much less tactile feedback than the same control on the MX-350. Also, it's shape is completely different. On the RF-20, it is kind of scalloped (for lack of a better word) and it forms a sharp edge that is uncomfortable on the thumb after a few successive uses. It's made of hard plastic unlike the rest of the RF-20's buttons which are the soft rubber, and this only makes it worse. The same control on the MX-350 is far more comfortable to use, and it make the entire remote feel like a much higher-quality unit.

3. We prefer the gemstone buttons to the soft rubber ones.

4. We like that you can have separate macros for each device on the Power On and Power Off buttons.

Also, we will probably never take advantage of it, but the MX-350's code database can be updated and it's programing & configuration can be archived and later reloaded using the PCL-300 ([Link: universalremote.com])

For us, it was no contest. The MX-350 is well worth the price difference.