I continue to be suprised by the number of individuals who have major problems with the IRIQ.
Perhaps I am just lucky. I have owned one since
early December and it replaced six remotes without any programming faults, transmit problems or delay problems. The devices it controls:

Sony TA-E2000 processor
Marantz DP-870 dd processor
Panasonic A-110 dvd player
Pioneer CL-D704 ld player
Pioneer PD-F1006 cd jukebox
Sony SLV-595 HF vcr
Zenith Pro 851 projector

The macros I have set up power up/down everything and perform all audio and video source selection without fail (some macros have as many as 10 commands). My Pioneer cd jukebox has a complex graphics/text display screen for disc/track selection that works better with the IRIQ wheel than the factory Pioneer remote.

I found the programming via the cd ideal for setup/configuration and very well designed.

I only hope that potential buyers of the IRIQ are not so turned off by the negative messages found here not to properly evaluate this device.
My dealer had one extensively configured at the store and took the time (about 45 minutes) to show me both the performance and programming.