Thanks for the valuable information! I literally came here for the purpose of sharing this same advice. I hadn't needed to program my MX-980 for a long time, but I couldn't for the life of me get it to work with Win 10 yesterday. After doing a lot of Googling, I came across the same solution that URC suggested. In my case, however, the solution had nothing to do specifically with the MX-980. I had noticed that Windows Mobile Device Center wasn't working properly, and I came across this page suggesting a fix ...

[Link: stackoverflow.com]

Hopefully, this will help others to avoid the headache we went through. :)