I own both a Harmony One and a Harmony 1000. I use them in different in different rooms of the house. I like the Harmony One way better. In fact, I keep the Harmony One where I have my main entertainment system since I'm in there more often. The shape and placement of the buttons on the One make it so much easier to use than the 1000. The LCD screen on the One is smaller, however, it looks much sharper. The graphics look amazing.

I highly recommend the One.