Right, but assuming one follows the tutorial displayed
on the computer, or if one called Harmony support, all
should be OK. Joe, are you pointing the original remote
at the bottom of the Harmony (opposite the end where the
USB cable plugs in)?

Can you learn IR commands from any of your other remotes??
If the Harmony cannot learn commands from any other remote
then maybe you have a defective IR learning port on the
remote. Other than that, sounds like you've followed pretty
much every trick in the book (short of standing on your
head and clapping at the same time).

In extreme cases, you can also request to send your original
remote to the Harmony head office in Canada so they can
learn the commands for you in their lab. Alternately you
could try learning the commands for your remote with another
Harmony (perhaps one of your friends has a Harmony you
could borrow).

One final note: the Harmony remotes can learn most but
not all types of IR signals, especially those in higher
frequencies or those emitting a high bit rate signal.
This problem is known to occur with Bang & Olufsen remotes
among others (Uverse is another that comes to mind, off
hand). In this case, you would probably need to send your
original remote to Harmony, or have the manufacturer provide
hex/binary codes for the remote IR commands so that Harmony
support can manually program the commands for you.