My HTPC is in fact running Windows 7 Home Premium 64-bit. EventGhost works without issue, so you should be good to go. When sending IR codes to your HTPC the left pane of EventGhost should capture the event which in turn you can associate with an action you've created in the right pane by peforming a simple drag and drop. Very easy software to use. In fact, I use EventGhost on my laptop as well to automate certain repetitive tasks I routinely perform with the remote control programming software that I use. Great program.