My experience with the four Harmony remotes I've owned is not at all like goldenzrule's. I've never had one fail. The software database has the discrete power on and power off codes for both my Onkyo and Denon receivers and uses them by default in the activities.

I agree the software is far from perfect, but I've been able to set up all of my activities to be easy for my wife and visitors to use. Not too bad considering I paid less than a hundred for each of them. I could have paid the big bucks for a pro remote, but these Harmony remotes seem to do everything I ask, albeit through a harder-to-use software wizard.