Well the R40 and older R50 do not give you the ability to edit a macro. If you want to make any changes to a macro, you have to erase it first, then re-create it with the new script. So if that's truly a deal breaker then you can scratch both of these units off your list. But i'm used to doing this with my stable of MX-500s over the years as well as MX-500s i've used on friends' and customers' systems so it doesn't bother me at all, and it is an acceptable flaw since i love my R40. This is the first consumer remote i've tried that can finally replace my beloved primary MX-500 (which i still use MX-500s in my other rooms - for now). I did briefly have an R50 but i returned it because of i didn't like the way it felt in my hand - it has an odd design and uncomfortable placement of the volume and transport keys. The R40 is way better in this regard and feels like a much more expensive and professional remote.