To pass the wife/mom/guest test, a universal remote must in my opinion have both a macro-programmable ON button and a macro-programmable OFF button. It is unbelievable how many universal remotes have failed to achieve this most important usability requirement after so many years of the industry providing universal remotes. When my Mom looks at my array of remotes and says, "So, which button turns it on?" I can tell you that it is essential to be totally clear on this fundamental starting point. Pressing the correct device button first is useless to someone unfamiliar with your system, and SO many universal remotes require this and fail to make the power botton macro-programmable. Macro is essential for choosing a "default" device when turning on so your guest can simply start watching TV and changing channels. There are so many universal remotes out there that would be so much more acceptable if they just made this one improvement: separate macro-programmable ON and OFF buttons.

Kudos to the Home Theater Master MX-500 and MX-700 for finally figuring this out and getting this right. (The MX-700, the latest, has evolved to the simplest, cleanest labeling: [ON] and [OFF] with the [ON] button in the upper-left, and I would like to see this simplicity carried back to the MX-500 in a revision or carried forward in the successor to the MX-500. The word "SYSTEM" over the "OFF" button adds undo complexity and "ON" on the button is more straightforward than "POWER" over the button with a graphic on the button.)

Does anyone know of any remotes other than the MX-500 and MX-700 that get ON and OFF right?

I know the RS 15-1902 and the Memorex CP4 had separate ON and OFF buttons.:)

you could put an on and off button on a Pronto :-)
There are many remotes that can do on/off macros.

on the other hand, remotes that are activity based (like the Harmony or some Pronto designs) don't have an on function labeled on since they tend to be labeled as the activity (i.e. "watch DVD" would turn on what is needed to watch a DVD)