Shady,
It all depends on what you want your remote to do! For many people, the One for All (OFA) or Radio Shack equivalent models are all they need.
The more expensive remotes offer more features, as you might expect. Macros, learning ability, extensive customizing ability, capable of controlling more devices, etc. Depending on the complexity of your system, these features may be "essential," or completely uneeded, or somewhere in between.
I would suggest that you first decide what you want your remote to do. Then read the box description or post a question to the OFA experts here about whether the inexpensive remote will do what you want. If "yes", you have your answer... come to think of it, if "no," you have your answer too!

Hope this helps. -Bruce