If you don't mind having the MRF-250 in plain view, it doesn't hurt to try it out in the blaster configuration. Make sure that the MRF-250 is on an address other than "0".
I prefer to hide the MRF and use the individual IR emitters for a cleaner installation. Find the IR receiving eye of each component (if it's not obvious, it will usually be shown in the manual) and temporarily place the emitter over that location (use a piece of removeable tape). Move the emitter around until you get reliable RF operation where the commands work every time. Then you can affix the emitter using the peel-and-stick pad. Also, see the instructions
here.
Not having a laptop isn't a problem. Just choose the IR database codes or files from this site for your components, download them and try them out. Learn any commands if necessary. Once you have a reliable set of commands, you can program macros using them.
Mike
www.SurfRemoteControl.com