I would stick with Universal's Remote. Just make sure that it is bought from a Authorized Dealer so you can get the software. you would also need a MRF unit to do the RF. I like using the MRF-300 It cost a little more then the 250 but is much better. When you use the MRF unit, you would connect emitters (which come with the unit) to each piece of gear that you want to control. Now you would use the software to program everything you want the system to do. For the Itunes remote you will probably have to learn the codes into the remote which is very easy to do. I like the MX remotes more than the harmony because you can customize more to how you want the remote to work. I also think that the Harmony button layout is a little weird, but that is only my opinion.