If the disc loading sequence your changers use is different then yes, you will need to make the needed modifications to the setup page seen here. Just make sure to keep the pre and post macro buttons, and number buttons 0-9 in tact as they are what make up the 400 disc loading macros. Also, make sure to read over the last section of this post entitled, "DVD Juke (DLM)". It goes over all of this in more detail.