I think you are right that it is the box. 01376 did give me two blinks but still no control of the box.. Also I can still work my TV and DVR with the remote, just not the set top box. I don't think I've introduced anything else into the environment and the remote has worked fine for almost two years. Comcast last advised me to bring in the remote and exchange it. But it sounds like that wouldn't solve the problem either if it is indeed the box