Ok, the current 880 has been great for the past 6 years, but it's beginning to die. It sometimes needs the battery to be reinserted to work, the firmware went hay-wire during a programing, among other things.
It's dieing for a number of reasons, one being that someone would fall asleep with the remote in had, and sweat.

Preferably, I want to be able to program it myself as if anything changes in the current setup, I don't want to pay anyone to re-program it.

Samsung TV LN52A750R1F
Onkyo TX-NR509
LG BP-530
Comcast cable box

I need it to do everything the 880 does.
It needs physical buttons.
It needs to be able to switch activities without an issue, leaving things on if they already one as well as offering a "help button" just in case.
It needs a master "off" button that will turn everything off except the cable box.
Needs to be able to withstand drops.

The reason being my mother will be using it, and it needs to be easy to use. If things get out of sync, it needs to be easy to get them back in sync.

I have heard some bad things about the Harmony Touch, so I want to avoid that one.

Budget should be as low as possible, maxed out at around $250

I basically just posted the same thing in another post. Based on you needs and budget the only option is another Harmony remote.

Well, no the Harmony isn't the only option.  JP1 remotes. like the RCA RCRP05B ($20) will do this job well.  So will the Comcast remote. although it would benefit from having one more device button.  The Samsung, LG, and Onkyo all have a full set of discrete IR commands, so a "help button" isn't necessary.  (It is also possible to setup some Harmonys so that they use discretes also.)  

The RCRP05B is highly reliable, and you can expect the batteries to last for at least a year.  Using the RMIR software, the remote can be used to power on and set the various inputs by pressing the TV, DVD, or Audio buttons. 

You will need to buy (or assemble) a JP1 flash cable ($20-$30).  The benefit is high relieability, long battery life, and  the system is cheap.

I think I am going to stick to the custom installers lounge. I don't even know how to respond to that.

Never had to do any programing like that, but it seems likme a good option.

As for not needing a "help" button, it's because ths TV's IR reciever is a little weak. Now we only need it to turn on and off, but it still has issues. Even with it's bundled remote.

The point of discrete power commands is if it doesn't turn on the first time, push the button again, and give it a second try.   If you use Logitech's power tracking scheme, then the remote will be out of synch with the TV, and Help is needed. Not the case with discrete functions.

Well, the TV and Blu-Ray player don’t have discrete power functions.

Had a bit of luck, I found a Harmony 900 for $150.
It's a refurbished one, but so is the 880 it's replacing.

And that's being ordered as it works out, my mom likes it, and can get extended coverage.

Thanks for the input! Honestly, if this one goes belly up, I'll probably really push for either a JP1 or URC. If I can at least backup settings from the URC as a precaution, that will be good enough. Just wish the stranded remotes had all options on them.

You'll actually find that your Samsung LN52A750R1F TV more than likely does have discrete power commands. They're just not present on the OEM remote.

If you dig into the options for the Samsung TV in Logitech MyRemote, you'll find three power commands:
- Power Toggle (the default one)
- Power On
- Power Off