I have note tried it myself but the process below is generally reported to work.
Getting MX 3000 and MX 980 connected using Windows Vista
Previously Microsoft has used Active Sync on most versions of windows operating systems as a mobile device manager. However, the new Windows Vista operating system uses a new synchronization platform called, “Windows Mobile Device Center.” Although Active Sync is no longer available for Vista, our MX 3000 and MX 980 model remote controls can still connect and sync with a Windows Vista based PC. Simply install mobile device center as outlined below:
A. Install Windows Mobile Device Center 6 from this address: [Link: microsoft.com]
B. Plug in the MX-3000/MX 980 Universal Remote. (Windows will automatically try to locate the drivers)
1. Right-click on "Computer" and select "Manage"
2. Open the Device Manager, next select the Mobile Device – URC USB Sync MX.
3. Right-click and select "Update driver..."
4. Select browse my computer for driver …
4. In the wizard, select "pick from a list of devices..."
5. In the list, select (Mobile devices)
6. Uncheck “show compatible hardware”
7. Select Microsoft "Microsoft USB Sync".
*You may have to unplug & plug it back in a few times
Ever get these messages when trying to do a “Live Update” with Vista?
(Fail to Download the Patch Info File, or Download Fail, or Unable to Download etc....)
Follow these steps (This helps a lot of the problems but not all)
1. Using an administrator account, go to Control Panel
2. Select User Accounts
3. Turn User Account Control on or off
4. Uncheck the (UAC) box
5. Restart the computer and open up Complete Control Suite & Live update at will.