JD,
I'm assuming this is new construction. That's a big back box to retro in.
Is there attic above? How will the speaker be installed after sheetrock, or be serviced?
Isolate the back box from the structure and the sheetrock. Use isolation mounts made of hardened rubber or neoprene to secure the sub enclosure to the wood structure. Set the box back just behind the sheetrock to no sound is transferred to the sheetrock.
You can find neoprene washers and grommets at Home Depot, or fancier stuff here
[Link: soundproofing.org]?
Go to the bottom of the page and check out the Super Soundproofing Hanging Vibration Isolation Pads- 60 Lb load limit. These may be overkill or not be able to fit in your application, but I've used them before to suspend a similar speaker cabinet like the RBH.
Hell, call one of those soundproofing companies, they might be able to help more.
Remember the most important principle; nothing hard (speaker back box MDF) touches nothing hard (the wooden joists, or the screw that attaches the back box to the joists). I've seen guys do a good job of using soft rubber washers and grommets to isolate, only to tighten the mounting screws too much and have the screws touching the speaker enclosure.
Oh, and insulate! Good luck, tell us how it works out.