I've a few MX-800's I use at work and Harmony 890 I just picked up to evaluate. Will probably move to the 1000 next month. Have programmed both myself and do believe the Harmony is a bit easier. The main difference I've found is the UR's you need to download or upload the controls/codes. With the Harmony all the codes/files are on their servers. When you add a device the files are there ready to use. You can also learn codes if necessary. Programming is not as easy as I would have throught, but does take some getting use to. But once you understand it, it's really quite good and not that bad.

Although you install the remote's software on your computer, I believe the files reside on Logitech servers. So you'll need an internet connection to change the files and update the remote. Also, their tech support, tier I & II, is extemely good.

Either way you go, both are good products.