KB
You can use both IR and RF on the remote at the same time, you just need to set each device accordingly. You can't do it on the same device (like a DVD player). You can get creative and split buttons up over two devices in the remote, for one actual device, if you have to. The newer rf6500 extender is so much better than direct IR, though, for ease of use and reliability, I use it all the time on installs.
Dan