The 890-PRO model is programmed much the same as other Harmony remotes thru the website. The biggest difference is the ability to have “rooms” and a Picture and Sound mode buttons.

It is more expensive as the 890-pro extender is not supplied with the remote and must be purchased separately.

It is only (legally) sold thru system integrators. Unless you really need the rooms feature or the sound and picture buttons I’d stick with the non-pro versions.