Hmmm, first I would try re-installing the firmware on the extender. Click the 'Downloads' button on your home page to find the firmware. Once the firmware update is complete, ensure your devices are mapped to the extender and update your remote and extender. Before you update, ensure you don't have your devices mapped to a specific IR port on the extender. Have everything set to 'All'.

Ensure the extender is plugged into an AC outlet and the middle light (the power light) is illuminated. Try using both the IR leads and the IR blaster on the extender that will control the device by placing the extender within line of sight of the device.

If this doesn't work.....try calling tech support. Could be a bad extender.