Rchamberlain, I use that "Next Generation" battery transmitter in my PVR (SA8300HD) remote to program my schedule recordings from my PC location which is far from my HT location. In my HT location, I use my Harmony 680 directly (without an IR repeater). Out of curiosity, I tried the Next Generation battery transmitter in my 680. It controlled all my equipment except the PVR (what an irony). Also note that the capacity of this 2/3 AAA NiMH battery is only about half a regular AAA NiMH (400 vs 800 mAh). So you will have to replaced the battery more often. This Next Generation battery transmitter is really meant for a simple remote that draws very little current in standby mode. In this case, the battery will last a long time (months) - self discharge will be the determining factor. Also note that RF repeaters (including this one) are prone to RF interference.
I recommend a wired IR repeater solution like the Hot Link Pro or the Niles system.