The Crestron CNMSX-AV only has eight discrete IR outputs. For more, I'd recommend stepping up to the Pro, and adding one or more CNX-IR cards (8 outputs each). You could add the cards to the AV with the optional Card Cage, but the cost would be very close to the Pro.
You could save another $1000 (or two), by using an ST-CP controller (instead of the CNMSX), and adding an Ocelot (via RS-232), and one (or more) SECU-16IR's (16 IR outputs each). For that matter, you could use a Pronto, instead of the 1550C and ST-CP -- but the Crestron is capable of MUCH more complicated logic, besides being RF and having a larger, brighter, more colorful screen.
Also, for anyone interested, there's a Crestron programmers' group on YahooGroups, at
[Link: groups.yahoo.com]