Try to make sure that each keypad follows some sort of template. Top button turns on the most used scene and the bottom button shuts off all lights in that room. Or top button turns on most used scene in that room and will also shut off all the lights in the room if there is already one light on. Second button down turns on the lights in the room next to the keypad, and so on and so forth.

I have found that most homeowners that have not lived with a lighting system want control of every light on an individual button. They want the top button to do one thing in one room and one thing in another. In six months they will hate the system because they always have to read the labels. In a well designed system when you want lights they should just press a button and not have to read it. Consistency is the only way to do this. When they walk into a room they should know what button to press to get the basic lighting scene, and not have to look at the keypad to do this.

Also try to minimize the number of pathways you use. If you have a path from every point A to every point B it will get very confusing. Have a few generic paths, if the house needs paths to begin with.