I've laid out a PCB using the software that is free at http://www.expresspcb.com An order of 20 pcb's from them would cost about $200 from them - or about $10 per board. I'll share my design with anyone who wants to go forward with it. My design does need to be critically examined and verified. It could be resized to fit into a Radio Shack project box.
I laid it out as a single sided board, and only needed a single jumper wire. Then I learned there's no cost savings at expresspcb for keeping it single sided. I laid it out with a board-mounted right-angle DB25 connector. The 6-pin is laid out as a 2x5 10-pin jumper with 4 pins unused, allowing use of the serial-port type cables. Component hole sizes should be verified.
Their software doesn't seem to be able to output standard PCB design files (gerber,etc). You release it's proprietary file to them for manufacture. It's pretty nice for being free.