Press the Windows key, in the search box type services.msc, when the window opens scroll down to Windows Mobile-2003-based device connectivity and click on it.
Now in the Log On tab change the setting to Local System account.

You should now be able to connect to your MX-6000 in Windows 10, it works on mine with a MX-6000.

Also IP works fine and I also have the itunes two way module working on my MX-6000

I got mine off Ebay for $60, would have never paid the new price because I prefer the wand remotes.