I have seen some random "cross talk" before. Once I could not explain it and neither could URC. The other house has 7 remotes and mrf350s. I went through and made sure all TVs were on different ports, same with directv and kscape players. Even with channel separation, different port assignments for similar devices, still intermittently, I hear of a TV turning in or off or a channel changing here and there while someone is using another remote in the house. I figure that one probably just has too many cooks in the kitchen :)