For a remote the MX-450 is a good option but tedious to program. I would look at one of URC's CCP remotes and find a dealer willing to give you the software. Surf remote control is company that does if you can't find a local dealer.

The difference between the Mx-450 and the CCP remotes is similar to the difference between typing on a keyboard and an old 10 digit flip phone. You can do it on the MX-450 but it is tedious and slow.

To program a CCP remote you need a windows computer, so if you live in Apple's playground for computers it will not work unless you use one the windows emulators. CCP will have a learning curve but once you learn it making changes and programming will be a lot easier, faster and offer way more flexibility.

Either the MX-450 or CCP models offer more flexibility in programming than a Harmony but they are no where near as quick or as easy to learn.