Depending on RAID implementation, some are go, no-go solutions, meaning that if it finds an error, it will stop and not proceed.

With that said, your choices are limited, so pick one from Daniel's extensive and well written options and go for it.

I have a fully loaded Norco 4220 file server and I'm dreading the day I have a catastrophic data failure. I'm using a software data replication with a JBOD scheme so that if I loose more than 2 drives, I still have some/most recoverable data.