I know this thread is over a year old, but I thought I'd add some new facts in case someone else gets here through a web search, like I did.

I just installed the 7.7 software, and before it let me do any programming it detected that I had the 650 connected and redirected me to the website. I'm trying to find a way around this, but I suspect that every time it auto-detects that a 650 is attached it will abort the setup and shunt me back to the MyHarmony website. That's fine for a basic user, but anyone who wants to use macros appears to be out of luck.

This stinks, because it really hamstrings the capabilities of this otherwise powerful device. Perhaps I can program my macros manually...