We've done dozens of acoustically transparent screens and never had a single problem. We have used some pretty massive speakers behind them as well (4' tall custom PSB speakers, large JBL Synthesis recessed in niches etc). One consideration you would want to address though...does the screen you are getting come with an additional layer of black material that goes behind the screen?

We tried a Draper screen to meet budget considerations at one point and it did not have black backing material so we could see the wall / speaker grills / speaker drivers. We decided to leave the grills off in the particular install. We had to paint the wall black and got some speaker cloth to cover the speakers.