I am not "absolutely sure"; I don't own a Harmony. But all Harmonys use the same data base. It isn't in the remote, and you'll actually download it from Logitech. They have a very large coverage. The only downside is that some of the signals are learned by users, and they could be dirty learns. The remotes I mentioned are sure to have perfect signals. But I'm quite sure that the Harmony will work. I think there website will tell you if they have an exact match.