You can do whatever you want to most anything that is remote-controllable! We've had an 1100 for our main system since mid-last year, and have been very please with how customizable it is. I have our sidebar buttons programmed to operate the dimmer switch (Lutron Maestro IR) for movie watching modes, using the RF wireless extender.

Just make sure when you set up your Activities, that you know all the correct inputs your gear should be set to. You can also read the 1100 thread over at AVS Forums for lots of good info...

FWIW, I've been using the Harmony remotes for many, many years now, starting with the (pre-Logitech buyout) Harmony 659. Then upgraded to the 880, then the One, and now the 1100.

Good luck!