TouchControl (http://www.touchapptech.com) can probably control the widest range of devices through direct integration with USB-UIRT, EventGhost, IRCommand2, Global Cache devices, HTTP servers, AutoHotKey, and directly to network-enabled devices (such as Denon receivers or Keene KIRA IR devices) via TCP or UDP sockets (UDP support is coming shortly in version 5.2). It's only drawback is it doesn't have a built-in IR database. But codes are easy enough to learn through the app or find on this site, and the ability to create 100% custom remote control layouts makes up for that, IMO.